Database : HANSEN
Search on : MODELOS ANIMAIS [Subject descriptor]
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Id:18272
Author:Job, Charles K
Title:Nine-banded armadillo and leprosy research ..-
Source:s.l; s.n; 2003. 10 p. ilus.
Abstract:In this presentation an attempt has been made to describe the nine-banded armadillo as an animal model, probably the only one in which lepromatous leprosy similar to that found in humans can be experimentally produced. Some unique features of the physiology of the animal are mentioned. The pathology and the microbiology of leprosy in the armadillo are described in detail. The discovery of lepromatous leprosy in the wild armadillos in the southern parts of United States, the transmission of disease among them through trauma and thorn pricks and the pathogenesis of the disease are presented. The impact of leprosy in the wild animals may have on human leprosy is discussed. (AU).
Descriptors:HANSENIASE VIRCHOWIANA/epidemiol
HANSENIASE VIRCHOWIANA/etiol
HANSENIASE VIRCHOWIANA/patol
HANSENIASE VIRCHOWIANA/transm
HANSENIASE VIRCHOWIANA/vet
TATUS/imunol
TATUS/microbiol
MODELOS ANIMAIS
 VETERINARIA DE SAUDE PÚBLICA
Limits:ANIMAL
Location:BR191.1; 00279/s


  2 / 11 HANSEN  
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Id:18119
Author:Binford, C. H
Title:Histiocytic granulomatous mycobacterial lesions produced in the golden hamster (cricetus auratus) inoculated with human leprosy: negative results in experiments using other animals ?-
Source:s.l; s.n; 1959. 24p p. ilus.
Abstract:1- During the past three years 35 experiments in inoculation with Mycobacterium leprae were undertaken on approximately 1500 animals. Total body irradiation and/or cortisone were used, in the hope of reducing host resistance. Because M. leprae in man grows best where the temperature is lower, the cooler parts of animals were inoculated. In all experiments, heat-treated inoculum was given to control animals. Histopathologic studies of the inoculation sites were made regularly. 2- Thirteen completed experiments on albino hamsters, white mice, white rats, hairless mice, and white guinea pigs have given negative results. 3- The histiocytic granulomatous lesions, in the testes and ears of the golden hamster approximately 18 months post inoculation, resembled human lepromatous leprosy in their histologic pattern, their number of intracellular acid-fast bacilli, and the presence of bacilli within nerves...AU.
Descriptors:HANSENIASE/microbiol
HANSENIASE/patol
HANSENIASE/transm
HANSENIASE/vet
ANIMAIS DE LABORATORIO/imunol
ANIMAIS DE LABORATORIO/microbiol
MODELOS ANIMAIS/imunol
 MESOCRICETUS/microbiol
Limits:HAMSTERS
Location:BR191.1; 00538/s


  3 / 11 HANSEN  
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Id:18118
Author:Collier, D. R
Title:Inoculation of monkeys with leprosy, following a diet of puak (colocasia) ?-
Source:s.l; s.n; 1940. 6p p. .
Abstract:A number of monkeys have been fed on a diet of colocasia, and then inoculated with material from lepers. All four female monkeys, so treated six or more months ago, have developed symptoms similar to those seen in leprosy in humans. There have been positive bacteriological findings in nodules and changes in pigmentation of the skin. One animal developed thickening of the ulnar nerves. One male monkey has developed abcesses containing acid-fast bacilli as well as other sympstoms after being injected with a solution of sapotoxin in addition to the diet of colocasia.
Descriptors:MYCOBACTERIUM LEPRAE/isol
MYCOBACTERIUM LEPRAE/patogen
HANSENIASE/microbiol
HANSENIASE/patol
HANSENIASE/transm
HANSENIASE/vet
ANIMAIS DE LABORATORIO/imunol
ANIMAIS DE LABORATORIO/microbiol
MODELOS ANIMAIS
 MESOCRICETUS
 MACACO
 cachorro
 coelho
 porquinho da índia
 porco
Limits:ANIMAL
Location:BR191.1; 00536/s


  4 / 11 HANSEN  
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Id:18117
Author:Soule, M. H; McKinley, E. B
Title:Cultivation of b. leprae with experimental lesions in monkeys ?-
Source:s.l; s.n; 1932. 36p p. ilus, tab.
Abstract:The experiments described include (1) the experimental production of granulomatous lesions suggestive of early lesions of leprosy in two species of monkeys by intradermal inoculation of human leprosy material; (2) the cultivation of acid-fast (presumably B. leprae) bacilli from human leprosy nodules on several artificial mediums in various gaseous environments; and (3) the experimental production of granulomatous lesions, suggestive of early leprosy, in two species of monkeys by the intradermal inoculation of cultures of acid-fast bacilli from human leprosy material grown on artificial mediums. We believe the experiments indicate a step forward in the fulfillment of Koch's postulates for the causative agent in the disease of leprosy.
Descriptors:HANSENIASE/microbiol
HANSENIASE/patol
HANSENIASE/transm
HANSENIASE/vet
MODELOS ANIMAIS
ANIMAIS DE LABORATORIO/imunol
ANIMAIS DE LABORATORIO/microbiol
Limits:ANIMAL
Location:BR191.1; 00565/s


  5 / 11 HANSEN  
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Id:18102
Author:Fernández, J. M. M
Title:The early reaction induced by lepromin ?-
Source:Rosario; s.n; 1940. 13p p. .
Abstract:The intradermal reaction to lepromin has been studied in a total of 563 persons, cases of leprosy and contacts. Observation of its clinical and histopathologic development has shown the following facts:a- In allergic cases intradermal injection of lepromin induces an "early" reaction which is well defined, both clinically and histologically, beginning a few hours after injection and reaching its maximum between 48 and 72 hours, thereafter decreasing until it disappears completely during the first week. b- This early reaction, which is manifested clinically by an erythematous halo, usually infiltrated, is not of nonspecific character since it has the histologic structure common to allergic reactions and is only seen in those cases which offer resistance to the infection (i.e., neural forms of the disease, particularly the tuberculoid form) and does not occur in cases which are considered anergic, as in the lepromatous type...AU.
Descriptors:ANTIGENO DE MITSUDA/admin
ANTIGENO DE MITSUDA/ef drogas
ANTIGENO DE MITSUDA/uso diag
MODELOS ANIMAIS
 MYCOBACTERIUM LEPRAE/cresc
 MYCOBACTERIUM LEPRAE/patogen
Limits:ANIMAL
Location:BR191.1; 00716/s


  6 / 11 HANSEN  
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Id:18086
Author:Gunders, A. E
Title:Progressive experimental infection with mycobacterium leprae in a chimpanzee ?-
Source:s.l; s.n; 1958. 3p p. ilus.
Descriptors:MYCOBACTERIUM LEPRAE/cresc
MYCOBACTERIUM LEPRAE/isol
MYCOBACTERIUM LEPRAE/patogen
MODELOS ANIMAIS
Location:BR191.1; 00567/s


  7 / 11 HANSEN  
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Texto Completo
Id:17623
Author:Rosa, Patricia Sammarco; Bolone, Andrea de Faria Fernandes; Silva, Eliane Aparecida.
Title:Mitsuda reaction in armadillos Dasypus novemcinctus using human and armadillo derived antigens.
Source:Hansen. int;30(2):180-184, Jul-Dez. 2005. tab.
Abstract:The armadillo has been an important experimental model for leprosy, besides it is still an important resource for bacilli. Despite the innumerous studies about armadillos of the Genus Dasypus, little is known about the real susceptibility of this species to the Hansen’s bacillus after experimental infection with M. leprae. Many authors have reported that 80 per cent of the inoculated animal will develop the disease. In Brazil, positive inoculation of this species was obtained only twice, being raised the hypothesis that these animals are more resistant to experimental infection. In the present study the response to the Mitsuda antigen was used as an indicative of cellular immune response to M. leprae in armadillos. Twenty one animals were tested with two Mitsuda antigen preparations, human derived (4,2 x 109 bacilli/ml) and armadillo derived (1,6 x 108 bacilli/ml) antigens. Response after 28 days of intradermal testing showed that most of the animals presented an infiltrate composed by grouped macrophages with vacuolated cytoplasm and rare lymphocytes. This response resembles lepromatous leprosy in humans and suggests that these animals would be susceptible to development of disseminated leprosy when successfully inoculated. Bacilloscopy in these animals varied from 3+ to 4+ according to Ridley’s scale (1966). Two animals developed a granulomatous reaction with borderline pattern and bacilloscopy varying from 1+ to 3+.AU.
Descriptors:ANTIGENO DE MITSUDA
MODELOS ANIMAIS
HANSENIASE/vet
Electronic Medium:Internet
Location:BR191.1


  8 / 11 HANSEN  
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Texto Completo
Id:17622
Author:Rosa, Patricia Sammarco; Belone, Andrea de Faria Fernandes; Silva, Eliane Aparecida.
Title:A reaçao de mitsuda em tatus Dasypus novemcinctus utilizando antigeno humano e antigeno derivado de tatus / Mitsuda reaction in armadillos Dasypus novemcinctus using human and armadillo derived antigens
Source:Hansen. int;30(2):174-179, Jul-Dez. 2005. ilus, tab.
Abstract:O tatu foi um modelo experimental importante para o estudo da hanseniase, alem de ser ainda uma importante fonte para coleta de bacilos. Apesar dos inumeros relatos de estudos em tatus de especie Dasypus novemcinctus, pouco se sabe sobre a real susceptibilidade desta especie ao bacilo de Hansen apos inoculaçao experimental com M. leprae. Alguns autores relatam que cerca de 80 por cento dos animais desenvolveriam a doença quando infectados. No Brasil, a inoculaçao experimental desta especie resultou em inoculaçoes positiva em apenas dois momento, tendo ate sido levantada a hipotese de estes animais serem mais resistentes a infecçao experimental. No presente estudo, utilizou-se a resposta ao nantigeno de Mitsuda como um indicador de resposta imune celular de tatus ao M. leprae...AU.
Descriptors:ANTIGENO DE MITSUDA
MODELOS ANIMAIS
HANSENIASE/vet
Electronic Medium:Internet
Location:BR191.1


  9 / 11 HANSEN  
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Texto Completo
Id:17546
Author:Diorio, Suzana Madeira; Manini, Marli Izabel Penteado; Trino, Lazara Moreira; Sartori, Beatriz Gomes Carreira; Opromolla, Diltor Vladimir Araujo.
Title:Resistance to dapsone and rifampin in Mycobacterium leprae isolated from leprosy patients of Sao Paulo State.
Source:Hansen. int;30(1):15-18, Jan-Jun 2005. tab.
Abstract:In 1981, reports of resistance to dapsone and rifampin led WHO to recommend multidrugtherapy in leprosy treatment. One of its main goals is preventing the selection of drug-resistant strains of mutant bacteria. Dapsone was the first drug which was experimentally proved to induce resistance; this became possible only after the mouse footpad inoculation technique was standardized, in 1960. There are some important criteria to suspect the existence of resistance, such as: relapses in multibacillary patients already treated or undergoing treatment or unsatisfactory clinical response. Our study aimed at detection of dapsone and rifampin resistant strains among 40 treated patients with clinical signs of relapse, from different cities of São Paulo State and its capital, employing the mouse footpad inoculation. We detected dapsone resistant bacilli in 11 cases. Among them, 5 showed total resistance, 1 intermediary resistance and 5 partial resistance. Rifampin resistant bacilli were detected in only two cases. We did not detect any case of multiple...(AU).
Descriptors:HANSENIASE/quimioter
HANSENOSTATICOS/uso terap
MYCOBACTERIUM LEPRAE/ef drogas
HANSENIASE/PATOL
 MODELOS ANIMAIS
Electronic Medium:Internet
Location:BR191.1


  10 / 11 HANSEN  
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Texto Completo
Id:17541
Author:Diorio, Suzana Madeira; Manini, Marli Izabel Penteado; Trino, Lazara Moreira; Sartori, Beatriz Gomes Carreira; Opromolla, Diltor Vladimir Araujo.
Title:Resistencia a dapsona e rifampicina em Mycobacterium leprae isolado de pacientes portadores de hanseniase no Estado de Sao paulo / Resistance to dapsone and rifampin in Mycobacterium leprae isolated from leprosy patients of Sao Paulo
Source:Hansen. int;30(1):09-14, Jan-Jun 2005. tab.
Abstract:Os relatos de resistencia e rifampicina fizeram com que a Organizaçao Mundial de Saude preconizasse, 1981, a poliquimioterapia para o tratamento da hanseniase. A prevençao da seleçao de cepas mutantes resistentes as drogas e um de seus principais objetivos. A dpsona foi a primeira droga a ter comprovação experimental de resistencia e isto so foi possivel depois que a tecnica de inoculaçao do bacilo em coxim plantar de camundongos foi padronizado em 1960. Criterios importantes a serem considerados para se suspeitar de resistencia seriam recidivas em pacientes multibacilares ja tratado, ou em tratamento, ou resposta clinica insatisfatoria. Nosso estudo teve por objetivo detectar cepas resistentes a dapsona e rifampicina entre 40 pacientes tratados com sinais clinicos de recidiva, procedentes de cidades do Estado de Sao paulo e capital, utilizando a tecnica de inoculaçao do em coxim plantar de camundongos. Foram observados bacilos resistentes a dapsona em 11 casos, sendo 05 de resistencia total, 01 intermediario e 05 parcial. Bacilos resistente a rifampicina foram observados em apenas 02 casos. Nao se observou nenhum caso de resistencia multipla. O alto indice obtido de resistencia a dapsona, provavelmente e decorrencia de muitos anos de monoterapia sulfonica ou de seus derivados. No caso da rifampicina, provavelmente a droga foi utilizada de forma irregular, em monoterapia ou aind, o paciente pode ter utilizado-a previamente para tratar outra molestia....(AU).
Descriptors:HANSENIASE/quimioter
HANSENOSTATICOS/uso terap
MYCOBACTERIUM LEPRAE/ef drogas
HANSENIASE/patol
 MODELOS ANIMAIS
Electronic Medium:Internet
Location:BR191.1


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Id:17540
Author:Paschoal, Vania Del'Arco; Rossit, Andrea Batista; Bizutti, Luiz O; Azoubel, Reinaldo.
Title:Volume dos nucleos das celulas do testiculo de ratos sob efeitos da ofloxacina / Study of nuclear volume of testicular cells in rats after the use of ofloxacin
Source:Hansen. int;30(1):03-08, Jan-Jun 2005. tab.
Abstract:A ofloxacina possui amplo aspectro de açao antimicrobiana, inclusive no combate ao Mycobacterium leprae, sendo atualmente empregada em substituiçao, quando da impossibilidade do uso da rifampicina. O objetivo deste foi estudar alteraçoes nos nucleos das celulas do testiculo de ratos puberes e respectivos grupos controle, submetidos a aplicaçao oral de ofloxacina. O metodo utilizado foi a morfometria, pela tecnica cariometrica. As principais estruturas observadas nas preparaçoes histologicas dos testiculos foram: as celulas de Leydig, as espermatogonias e as celulas de Setoli. Foram utilizados 09 ratos (Wistar), cinco tratados e quatro controles, aos quais foram administrados diariamente 12 mg/kg/peso de ofloxacina, do 34º ao 48º dia apos o nascimento. No 49º dia de vida, os ratos foram sacrificados. O estudo cariometrico das celulas de Leydig, das espermatogonias e das celulas de Sertoli de testiculos dos animais tratados nao evidenciou mudanças significativas na forma de seus nucleos (p>0,05), quando comparados aos controles. Conclui-se que a oflocaxina na dose e periodo empregados nao promoveu alteraçoes nos constituintes celulares de testiculos de ratos pubers. (AU).
Descriptors:HANSENIASE
HANSENOSTATICOS
MODELOS ANIMAIS
Electronic Medium:Internet
Location:BR191.1



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